Global sensitivity and identifiability implications in systems biology
نویسندگان
چکیده
منابع مشابه
Global Sensitivity and Identifiability Implications in Systems Biology
In systems biology, a common approach to model biological processes is to use large systems of differential equations.The associated parameter estimation problem requires to prior handle identifiability and sensitivity issues in a practical biological framework. The lack of method to assess global practical identifiability has leaded us to analyze and establish bridges between global sensitivit...
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A powerful way of gaining insight into biological systems is by creating a nonlinear differential equation model, which usually contains many unknown parameters. Such a model is called structurally identifiable if it is possible to determine the values of its parameters from measurements of the model outputs. Structural identifiability is a prerequisite for parameter estimation, and should be a...
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The relevance of model identifiability in system biology is well known. The aim of this paper is to discuss and possibly clarify the role and differences of two different methodologies of testing identifiability of models described by differential equations. One is called structural identifiability and does not require to use data collected in the experiment which, instead, data-based approache...
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ژورنال
عنوان ژورنال: IFAC Proceedings Volumes
سال: 2010
ISSN: 1474-6670
DOI: 10.3182/20100707-3-be-2012.0045